Wyatt Technology Corporation will be co-presenting a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the webinar will take place on 9 September 2014 at 11:00 AM EST/ 4pm GMT.
Due to the inherent instability of proteins and their tendency to aggregate under certain thermal and chemical conditions, screening and stability studies are an essential part of the development process for biologic formulations. However, the time and resources associated with manual processes often restrict the number of formulations that can be screened. By automating formulation preparation, screening and stability studies companies can increase their productivity and throughput without the need for additional resources as well as broadening the formulation design space.
Russell Burge, PhD, applications scientist at Freeslate, will present Freeslate’s biologics formulation system (BFS), an integrated workspace system that performs fully automated formulation preparation, screening and stability studies for the development of biotherapeutics. The system supports a number of analytical tools, including Wyatt Technology’s DynaPro Plate Reader II. Daniel Some, PhD, principal scientist at Wyatt, will introduce dynamic light scattering (DLS) as implemented in the DynaPro to quantify molecular size and aggregation state, assess aggregation propensity and determine formulation viscosity. When integrated with the Freeslate BFS, the temperature ramps and aggregation data provided by the DynaPro enable researchers to test more formulations, more rapidly, compared to manual operations, leading to greater productivity and confidence in the results.
Dr Some, who also serves as director of marketing at Wyatt Technology, explained: “Optimisation of the biologic drug formulation process is a key consideration for biopharmaceutical companies who invest significant resources in preclinical drug development. The integration of the DynaPro Plate Reader II with the Freeslate BFS enables researchers to dramatically increase the throughput and design space of their analyses. By providing comprehensive, automated testing over a range of conditions in minimal time, the Freeslate BFS combined with the DynaPro successfully meets the needs of our customers who are looking for a solution to the challenges associated with the development of safe, stable and effective biologic formulations. This webinar will provide a great opportunity to discover the latest developments in the automation of biologics formulation screening and stability studies.”