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clinical study

Singapore-based biotech company, Lion TCR, has received approval from the Health Services Authority (HSA) of Singapore for its Phase I/II multicentre clinical study of its T cell engineered immunotherapy for the treatment of liver cancer. more

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According to a recently published study, there may be a potential class of drugs that could be administered to people suffering from sudden liver failure that could reduce the need for transplantation surgery. more

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Commercial stage biotechnology acceleration development company, Q BioMed, has extended its option agreement with Washington University in St Louis for a novel companion biomarker for monitoring glaucoma and initiation of a clinical study. more

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A study involving pregnant women has been stopped immediately at a Dutch university after an increased risk of death and adverse effects for the baby after birth were revealed in the interim results. more

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Pfizer and Spark Therapeutics have announced that the Phase III programme for the investigational haemophilia B gene therapy is to be initiated by Pfizer. more

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Positive topline results from the Phase II clinical study assessing an anti-amyloid beta protofibril antibody in patients with early Alzheimer’s disease have been revealed by Eisai and Biogen. more

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The Independent Data Monitoring Committee (IDMC) has approved the continuation of the Phase III clinical study into OSE Immunotherapeutics’ treatment for Non-Small Cell Lung Cancer (NSCLC) — Tedopi — after immune checkpoint inhibitor treatment. more

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A study from the World Health Organisation (WHO) has revealed that a new formulation of a drug that prevents excessive bleeding in women following childbirth could save thousands of women’s lives in low and lower-middle income countries. more

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Operating clinical studies with a silo mentality with undoubtedly yield poor results. With various risks associated at each stage Adrian Collins, Almac Clinical Services, explores the hidden challenges of clinical packaging and how to overcome them… more

Opinion

According to a new study from the University of Eastern Finland and the German Center for Neurodegenerative Diseases, DZNE, antiepileptic drugs are associated with an increased risk of Alzheimer’s disease and dementia. more

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Danish biotech company, Acesion Pharma, has started the Phase I clinical study for its lead compound AP30663, which demonstrated a good safety profile and efficacy in converting AF to normal sinus rhythm in the preclinical development programme. more

Technology

Two recently published clinical studies have demonstrated a new approach using antibodies to target specific chemicals in the brain may help significantly reduce the incidence and severity of migraines. more

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First patient has been implanted with a novel drug delivery system, developed by Renishaw, for a new clinical study investigating it as a delivery method for cerebral dopamine neurotrophic factor (CDNF) as a treatment for Parkinson’s disease. more

Technology

Clinical stage biopharmaceutical company, X4 Pharmaceuticals, has secured $27 million in series B funding that will be used to advance its two lead drug candidates in clinical efficacy studies in immune-oncology and a pivotal study in a rare disease. more

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A new study from industry and academia has highlighted a new approach to targeting key cancer-linked proteins that are considered to be ‘undruggable’. more

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A research team from the Netherlands Cancer Institute has discovered the underlying mechanism to why cancer cells become addicted to the drugs that are administered to kill them, which may lead to more rational alternating therapies. more

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According to a survey released by Tufts Center for the Study of Drug Development, ‘2017 eClinical Landscape Study’, the length of time it takes companies to build and release a clinical study database is having a negative effect on trial completion more

Analysis

Clinical-stage, biopharmaceutical start-up company, Autolus, steps into the chimeric antigen receptor (CAR)-T cell therapy fray with three new studies looking at the treatment of various cancers. more

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Interim results from the advanced renal cell carcinoma (RCC) cohort of a study evaluating Kisplyx (lenvatinib) in combination with Merck’s anti-PD-1 therapy, pembrolizumab (KEYTRUDA), have been announced by Eisai. more

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A new clinical study from a team at Lund University, Sweden, has shown that Probi’s probiotics support the immune system and slow down the onset of gluten intolerance in children. more

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