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clinical study

According to a new study from the University of Eastern Finland and the German Center for Neurodegenerative Diseases, DZNE, antiepileptic drugs are associated with an increased risk of Alzheimer’s disease and dementia. more

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Danish biotech company, Acesion Pharma, has started the Phase I clinical study for its lead compound AP30663, which demonstrated a good safety profile and efficacy in converting AF to normal sinus rhythm in the preclinical development programme. more

Technology

Two recently published clinical studies have demonstrated a new approach using antibodies to target specific chemicals in the brain may help significantly reduce the incidence and severity of migraines. more

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First patient has been implanted with a novel drug delivery system, developed by Renishaw, for a new clinical study investigating it as a delivery method for cerebral dopamine neurotrophic factor (CDNF) as a treatment for Parkinson’s disease. more

Technology

Clinical stage biopharmaceutical company, X4 Pharmaceuticals, has secured $27 million in series B funding that will be used to advance its two lead drug candidates in clinical efficacy studies in immune-oncology and a pivotal study in a rare disease. more

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A new study from industry and academia has highlighted a new approach to targeting key cancer-linked proteins that are considered to be ‘undruggable’. more

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A research team from the Netherlands Cancer Institute has discovered the underlying mechanism to why cancer cells become addicted to the drugs that are administered to kill them, which may lead to more rational alternating therapies. more

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According to a survey released by Tufts Center for the Study of Drug Development, ‘2017 eClinical Landscape Study’, the length of time it takes companies to build and release a clinical study database is having a negative effect on trial completion more

Analysis

Clinical-stage, biopharmaceutical start-up company, Autolus, steps into the chimeric antigen receptor (CAR)-T cell therapy fray with three new studies looking at the treatment of various cancers. more

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Interim results from the advanced renal cell carcinoma (RCC) cohort of a study evaluating Kisplyx (lenvatinib) in combination with Merck’s anti-PD-1 therapy, pembrolizumab (KEYTRUDA), have been announced by Eisai. more

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A new clinical study from a team at Lund University, Sweden, has shown that Probi’s probiotics support the immune system and slow down the onset of gluten intolerance in children. more

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A study, from an international team of researchers, may offer hope to patients with prostate cancer as it shows that a combination therapy could potentially reduce the recurrence rate of the disease. more

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Primary data from the CANTOS Phase III trial (sponsored by Novartis) has revealed that a treatment that targets inflammation reduces the risk of cardiovascular disease. more

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The Alliance Foundation Trials (AFT) — in conjunction with Pfizer and six international cancer research groups — has launched a randomised open-label Phase III clinical study, PATINA, to evaluate a combination therapy for breast cancer. more

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Findings published in Nature Communications from nanoengineers at the University of California San Diego, have demonstrated the success of drug delivery by micromotors to treat bacterial infections in the stomach. more

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Biotechnology company, MIMETAS, in collaboration with pharmaceutical company, Roche, has developed an organ-on-a-chip system that supports the evaluation of intestinal permeability in perfused 3D gut tubules when exposed to pharmacological compounds. more

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A recent study, published in Nature Communications, has described how a candidate synthetic vaccine for polio has been developed with a method grown in plants that use virus like particles (VLPs). more

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A potential new therapy for type I diabetes patients has been found to be safe and does not accelerate decline in β cell function — important in the production of insulin — in a recently published clinical trial. more

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A recent study from the University of Eastern Finland has demonstrated that proton pump inhibitors, commonly used as antiulcer drugs in older patients, do not increase the risk of Alzheimer’s disease. more

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A new study, led by University College London, has demonstrated that a diabetes drug (exenatide) may offer potentially disease-modifying attributes to patients suffering from Parkinson’s disease. more

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